Targeting Human Telomeric G-Quadruplex DNA and Inhibition of Telomerase Activity With [(dmb)(2)Ru(obip)Ru(dmb)(2)](4+)

Inhibition of telomerase by inducing/stabilizing G-quadruplex formation is a promising strategy to design new anticancer drugs. We synthesized and characterized a new dinuclear complex [(dmb)(2)Ru(obip)Ru(dmb)(2)](4+) (dmb = 4,4’-dimethyl-2,2’-bipyridine, obip = (2-(2-pyridyl)imidazo[4,5-f][1,10]phe...

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Detalles Bibliográficos
Autores principales: Shi, Shuo, Gao, Shane, Cao, Tongcheng, Liu, Jie, Gao, Xing, Hao, Jian, Lv, Chunyan, Huang, Hailiang, Xu, Jun, Yao, Tianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874006/
https://www.ncbi.nlm.nih.gov/pubmed/24386376
http://dx.doi.org/10.1371/journal.pone.0084419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874006/
https://www.ncbi.nlm.nih.gov/pubmed/24386376
http://dx.doi.org/10.1371/journal.pone.0084419

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