Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites

We applied Illumina Human Methylation450K array to perform a genomic-scale single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily glial) nuclei separated from the orbitofrontal cortex of postmortem human brain. The findings were validated using enhanced reduced repres...

Descripción completa

Detalles Bibliográficos
Autores principales: Kozlenkov, Alexey, Roussos, Panos, Timashpolsky, Alisa, Barbu, Mihaela, Rudchenko, Sergei, Bibikova, Marina, Klotzle, Brandy, Byne, William, Lyddon, Rebecca, Di Narzo, Antonio Fabio, Hurd, Yasmin L., Koonin, Eugene V., Dracheva, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874157/
https://www.ncbi.nlm.nih.gov/pubmed/24057217
http://dx.doi.org/10.1093/nar/gkt838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874157/
https://www.ncbi.nlm.nih.gov/pubmed/24057217
http://dx.doi.org/10.1093/nar/gkt838

Ejemplares similares