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The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domain

Cdc13, the telomere end-binding protein from Saccharomyces cerevisiae, is a multidomain protein that specifically binds telomeric single-stranded DNA (ssDNA) with exquisitely high affinity to coordinate telomere maintenance. Recent structural and genetic data have led to the proposal that Cdc13 is t...

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Detalles Bibliográficos
Autores principales: Lewis, Karen A., Pfaff, Danielle A., Earley, Jennifer N., Altschuler, Sarah E., Wuttke, Deborah S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874162/
https://www.ncbi.nlm.nih.gov/pubmed/24057216
http://dx.doi.org/10.1093/nar/gkt843