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Handling the 3-methylcytosine lesion by six human DNA polymerases members of the B-, X- and Y-families
Alkylating agents often generate 3-methylcytosine (3meC) lesions that are efficiently repaired by AlkB homologues. If AlkB homologue proteins are not functional, or the number of 3meC lesions exceeds the cellular repair capacity, the damage will persist in the genome and become substrate of DNA poly...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874200/ https://www.ncbi.nlm.nih.gov/pubmed/24097443 http://dx.doi.org/10.1093/nar/gkt889 |