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Handling the 3-methylcytosine lesion by six human DNA polymerases members of the B-, X- and Y-families

Alkylating agents often generate 3-methylcytosine (3meC) lesions that are efficiently repaired by AlkB homologues. If AlkB homologue proteins are not functional, or the number of 3meC lesions exceeds the cellular repair capacity, the damage will persist in the genome and become substrate of DNA poly...

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Detalles Bibliográficos
Autores principales: Furrer, Antonia, van Loon, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874200/
https://www.ncbi.nlm.nih.gov/pubmed/24097443
http://dx.doi.org/10.1093/nar/gkt889

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