Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

LINE-1 (L1) retrotransposons are mobile genetic elements whose extensive proliferation resulted in the generation of ∼34% of the human genome. They have been shown to be a cause of single-gene diseases. Moreover, L1-encoded endonuclease can elicit double-strand breaks that may lead to genomic instab...

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Detalles Bibliográficos
Autores principales: Horn, Axel V., Klawitter, Sabine, Held, Ulrike, Berger, André, Jaguva Vasudevan, Ananda Ayyappan, Bock, Anja, Hofmann, Henning, Hanschmann, Kay-Martin O., Trösemeier, Jan-Hendrik, Flory, Egbert, Jabulowsky, Robert A., Han, Jeffrey S., Löwer, Johannes, Löwer, Roswitha, Münk, Carsten, Schumann, Gerald G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874205/
https://www.ncbi.nlm.nih.gov/pubmed/24101588
http://dx.doi.org/10.1093/nar/gkt898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874205/
https://www.ncbi.nlm.nih.gov/pubmed/24101588
http://dx.doi.org/10.1093/nar/gkt898

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