The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...

Descripción completa

Detalles Bibliográficos
Autores principales: Steiner, Michel A., Sciarretta, Carla, Pasquali, Anne, Jenck, Francois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874552/
https://www.ncbi.nlm.nih.gov/pubmed/24416020
http://dx.doi.org/10.3389/fphar.2013.00165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874552/
https://www.ncbi.nlm.nih.gov/pubmed/24416020
http://dx.doi.org/10.3389/fphar.2013.00165

Ejemplares similares