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The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...

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Detalles Bibliográficos
Autores principales:	Steiner, Michel A., Sciarretta, Carla, Pasquali, Anne, Jenck, Francois
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874552/ https://www.ncbi.nlm.nih.gov/pubmed/24416020 http://dx.doi.org/10.3389/fphar.2013.00165

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