Protonation controls ASIC1a activity via coordinated movements in multiple domains

Acid-sensing ion channels (ASICs) are neuronal Na(+)-conducting channels activated by extracellular acidification. ASICs are involved in pain sensation, expression of fear, and neurodegeneration after ischemic stroke. Functional ASICs are composed of three identical or homologous subunits, whose ext...

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Detalles Bibliográficos
Autores principales: Bonifacio, Gaetano, Lelli, Cláudia Igutti Suenaga, Kellenberger, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874563/
https://www.ncbi.nlm.nih.gov/pubmed/24344244
http://dx.doi.org/10.1085/jgp.201311053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874563/
https://www.ncbi.nlm.nih.gov/pubmed/24344244
http://dx.doi.org/10.1085/jgp.201311053

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