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Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

Sugars that contain glucose, such as sucrose, are generally preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates striatal dopamine (DA) release. While the post-ingestive rewarding effect, which artificial sweeteners do not have, signals the nutrient value...

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Autores principales: Domingos, Ana I, Sordillo, Aylesse, Dietrich, Marcelo O, Liu, Zhong-Wu, Tellez, Luis A, Vaynshteyn, Jake, Ferreira, Jozelia G, Ekstrand, Mats I, Horvath, Tamas L, de Araujo, Ivan E, Friedman, Jeffrey M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875383/
https://www.ncbi.nlm.nih.gov/pubmed/24381247
http://dx.doi.org/10.7554/eLife.01462
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author Domingos, Ana I
Sordillo, Aylesse
Dietrich, Marcelo O
Liu, Zhong-Wu
Tellez, Luis A
Vaynshteyn, Jake
Ferreira, Jozelia G
Ekstrand, Mats I
Horvath, Tamas L
de Araujo, Ivan E
Friedman, Jeffrey M
author_facet Domingos, Ana I
Sordillo, Aylesse
Dietrich, Marcelo O
Liu, Zhong-Wu
Tellez, Luis A
Vaynshteyn, Jake
Ferreira, Jozelia G
Ekstrand, Mats I
Horvath, Tamas L
de Araujo, Ivan E
Friedman, Jeffrey M
author_sort Domingos, Ana I
collection PubMed
description Sugars that contain glucose, such as sucrose, are generally preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates striatal dopamine (DA) release. While the post-ingestive rewarding effect, which artificial sweeteners do not have, signals the nutrient value of sugar and influences food preference, the neural circuitry that mediates the rewarding effect of glucose is unknown. In this study, we show that optogenetic activation of melanin-concentrating hormone (MCH) neurons during intake of the artificial sweetener sucralose increases striatal dopamine levels and inverts the normal preference for sucrose vs sucralose. Conversely, animals with ablation of MCH neurons no longer prefer sucrose to sucralose and show reduced striatal DA release upon sucrose ingestion. We further show that MCH neurons project to reward areas and are required for the post-ingestive rewarding effect of sucrose in sweet-blind Trpm5(−/−) mice. These studies identify an essential component of the neural pathways linking nutrient sensing and food reward. DOI: http://dx.doi.org/10.7554/eLife.01462.001
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spelling pubmed-38753832014-01-01 Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar Domingos, Ana I Sordillo, Aylesse Dietrich, Marcelo O Liu, Zhong-Wu Tellez, Luis A Vaynshteyn, Jake Ferreira, Jozelia G Ekstrand, Mats I Horvath, Tamas L de Araujo, Ivan E Friedman, Jeffrey M eLife Human Biology and Medicine Sugars that contain glucose, such as sucrose, are generally preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates striatal dopamine (DA) release. While the post-ingestive rewarding effect, which artificial sweeteners do not have, signals the nutrient value of sugar and influences food preference, the neural circuitry that mediates the rewarding effect of glucose is unknown. In this study, we show that optogenetic activation of melanin-concentrating hormone (MCH) neurons during intake of the artificial sweetener sucralose increases striatal dopamine levels and inverts the normal preference for sucrose vs sucralose. Conversely, animals with ablation of MCH neurons no longer prefer sucrose to sucralose and show reduced striatal DA release upon sucrose ingestion. We further show that MCH neurons project to reward areas and are required for the post-ingestive rewarding effect of sucrose in sweet-blind Trpm5(−/−) mice. These studies identify an essential component of the neural pathways linking nutrient sensing and food reward. DOI: http://dx.doi.org/10.7554/eLife.01462.001 eLife Sciences Publications, Ltd 2013-12-31 /pmc/articles/PMC3875383/ /pubmed/24381247 http://dx.doi.org/10.7554/eLife.01462 Text en Copyright © 2013, Domingos et al http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Human Biology and Medicine
Domingos, Ana I
Sordillo, Aylesse
Dietrich, Marcelo O
Liu, Zhong-Wu
Tellez, Luis A
Vaynshteyn, Jake
Ferreira, Jozelia G
Ekstrand, Mats I
Horvath, Tamas L
de Araujo, Ivan E
Friedman, Jeffrey M
Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
title Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
title_full Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
title_fullStr Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
title_full_unstemmed Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
title_short Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
title_sort hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
topic Human Biology and Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875383/
https://www.ncbi.nlm.nih.gov/pubmed/24381247
http://dx.doi.org/10.7554/eLife.01462
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