Cargando…

Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model

Mortalin is an essential component of the molecular machinery that imports nuclear-encoded proteins into mitochondria, assists in their folding, and protects against damage upon accumulation of dysfunctional, unfolded proteins in aging mitochondria. Mortalin dysfunction associated with Parkinson’s d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Jun-yi, Vereshchagina, Natalia, Sreekumar, Vrinda, Burbulla, Lena F., Costa, Ana C., Daub, Katharina J., Woitalla, Dirk, Martins, L. Miguel, Krüger, Rejko, Rasse, Tobias M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875477/ https://www.ncbi.nlm.nih.gov/pubmed/24386261 http://dx.doi.org/10.1371/journal.pone.0083714

Ejemplares similares

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1
por: Burbulla, L F, et al.
Publicado: (2014)

Similarities and Differences of Hsp70, hsc70, Grp78 and Mortalin as Cancer Biomarkers and Drug Targets
por: Rai, Rajani, et al.
Publicado: (2021)

Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila
por: Zhu, Jun-yi, et al.
Publicado: (2021)

Hsc70 is required for endocytosis and clathrin function in Drosophila
por: Chang, Henry C., et al.
Publicado: (2002)

Hsc70’s trip to the tip
por: Leslie, Mitch
Publicado: (2015)

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly
por: Xing, Yi, et al.
Publicado: (2010)

Comparative analysis of the anticoagulant activities and immunogenicity of HSC70 and HSC70(TKD) of Haemaphysalis flava
por: Liu, Yu-Ke, et al.
Publicado: (2022)

Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers
por: Brady, Emily B., et al.
Publicado: (2023)

Mortalin, Apoptosis, and Neurodegeneration
por: Londono, Carolina, et al.
Publicado: (2012)

Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model
por: Füger, Petra, et al.
Publicado: (2012)

Correction: Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model
por: Füger, Petra, et al.
Publicado: (2013)

Variants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson’s Disease Patients
por: Berenguer-Escuder, Clara, et al.
Publicado: (2019)

The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila
por: Chang, Henry C., et al.
Publicado: (2004)

Mechanism and Complex Roles of HSC70 in Viral Infections
por: Wang, Zeng, et al.
Publicado: (2020)

Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70
por: Hong, Zhouping, et al.
Publicado: (2022)

Editorial: The role of mortalin in biology and disease
por: Park, Jong-In
Publicado: (2023)

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells
por: Ryu, Seung W., et al.
Publicado: (2020)

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1
por: Krebiehl, Guido, et al.
Publicado: (2010)

Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIP
por: Soss, Sarah E., et al.
Publicado: (2015)

Clinical Relevance of Mortalin in Ovarian Cancer Patients
por: Rajtak, Alicja, et al.
Publicado: (2023)

Hsp70 Architecture: The Formation of Novel Polymeric Structures of Hsp70.1 and Hsc70 after Proteotoxic Stress
por: Steel, Rohan, et al.
Publicado: (2012)

Hsc70-4 aggravates PolyQ-mediated neurodegeneration by modulating NF-κB mediated immune response in Drosophila
por: Rai, Saurabh, et al.
Publicado: (2022)

Insights from the protein sequence and structure analysis of PgHsc70 and OsHsp70 genes
por: Baloji, Gugulothu, et al.
Publicado: (2022)

The Kinesin-3, Unc-104 Regulates Dendrite Morphogenesis and Synaptic Development in Drosophila
por: Kern, Jeannine V., et al.
Publicado: (2013)

Human Mitochondrial Hsp70 (Mortalin): Shedding Light on ATPase Activity, Interaction with Adenosine Nucleotides, Solution Structure and Domain Organization
por: Dores-Silva, Paulo R., et al.
Publicado: (2015)

Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin
por: Ganguly, Archan, et al.
Publicado: (2017)

Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes
por: Chen, Bo-Hua, et al.
Publicado: (2020)

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR
por: Baaklini, Imad, et al.
Publicado: (2020)

Clinical Implications of HSC70 Expression in Clear Cell Renal Cell Carcinoma
por: Zhang, Yixiao, et al.
Publicado: (2021)

Relevance of mortalin to cancer cell stemness and cancer therapy
por: Yun, Chae-Ok, et al.
Publicado: (2017)

Why is Mortalin a Potential Therapeutic Target for Cancer?
por: Yoon, A-Rum, et al.
Publicado: (2022)

The 70-kD heat shock cognate protein (hsc70) facilitates the nuclear export of the import receptors
por: Kose, Shingo, et al.
Publicado: (2005)

The Lid Domain of Caenorhabditis elegans Hsc70 Influences ATP Turnover, Cofactor Binding and Protein Folding Activity
por: Sun, Li, et al.
Publicado: (2012)

Different levels of hsp70 and hsc70 mRNA expression in Iberian fish exposed to distinct river conditions
por: Jesus, Tiago F., et al.
Publicado: (2013)

A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens
por: Baek, Kyung-Hwa, et al.
Publicado: (2015)

Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70)
por: Yang, Ximeng, et al.
Publicado: (2018)

Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum–associated degradation
por: Matsumura, Yoshihiro, et al.
Publicado: (2011)

Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70
por: Yagi, Hideshi, et al.
Publicado: (2017)

Rabies viruses leader RNA interacts with host Hsc70 and inhibits virus replication
por: Zhang, Ran, et al.
Publicado: (2017)

Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses
por: Banks, Susan M. L., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l008u4dljrnts5ikmqgi6t8bke