MiR-17-5p Impairs Trafficking of H-ERG K(+) Channel Protein by Targeting Multiple ER Stress-Related Chaperones during Chronic Oxidative Stress

BACKGROUND: To investigate if microRNAs (miRNAs) play a role in regulating h-ERG trafficking in the setting of chronic oxidative stress as a common deleterious factor for many cardiac disorders. METHODS: We treated neonatal rat ventricular myocytes and HEK293 cells with stable expression of h-ERG wi...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Hu, Weina, Lei, Mingming, Wang, Yong, Yan, Bing, Liu, Jun, Zhang, Ren, Jin, Yuanzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875566/
https://www.ncbi.nlm.nih.gov/pubmed/24386440
http://dx.doi.org/10.1371/journal.pone.0084984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875566/
https://www.ncbi.nlm.nih.gov/pubmed/24386440
http://dx.doi.org/10.1371/journal.pone.0084984

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