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MiR-17-5p Impairs Trafficking of H-ERG K(+) Channel Protein by Targeting Multiple ER Stress-Related Chaperones during Chronic Oxidative Stress
BACKGROUND: To investigate if microRNAs (miRNAs) play a role in regulating h-ERG trafficking in the setting of chronic oxidative stress as a common deleterious factor for many cardiac disorders. METHODS: We treated neonatal rat ventricular myocytes and HEK293 cells with stable expression of h-ERG wi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875566/ https://www.ncbi.nlm.nih.gov/pubmed/24386440 http://dx.doi.org/10.1371/journal.pone.0084984 |