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Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1

Metastatic colorectal cancer (CRC) is incurable for most patients. Since mammalian target of rapamycin (mTOR) has been suggested as a crucial modulator of tumor biology, we aimed at evaluating the effectiveness of mTOR targeting for CRC therapy. To this purpose, we analyzed mTOR expression and the e...

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Detalles Bibliográficos
Autores principales: Francipane, Maria Giovanna, Lagasse, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875761/
https://www.ncbi.nlm.nih.gov/pubmed/24185040