Ascorbic acid insufficiency induces the severe defect on bone formation via the down-regulation of osteocalcin production

The L-gulono-γ-lactone oxidase gene (Gulo) encodes an essential enzyme in the synthesis of ascorbic acid from glucose. On the basis of previous findings of bone abnormalities in Gulo(-/-) mice under conditions of ascorbic acid insufficiency, we investigated the effect of ascorbic acid insufficiency...

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Detalles Bibliográficos
Autores principales: Kim, Won, Bae, Seyeon, Kim, Hyemin, Kim, Yejin, Choi, Jiwon, Lim, Sun Young, Lee, Hei Jin, Lee, Jihyuk, Choi, Jiyea, Jang, Mirim, Lee, Kyoung Eun, Chung, Sun G., Hwang, Young-il, Kang, Jae Seung, Lee, Wang Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Anatomists 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875843/
https://www.ncbi.nlm.nih.gov/pubmed/24386598
http://dx.doi.org/10.5115/acb.2013.46.4.254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875843/
https://www.ncbi.nlm.nih.gov/pubmed/24386598
http://dx.doi.org/10.5115/acb.2013.46.4.254

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