Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

RNA-guided endonucleases (RGENs), derived from the prokaryotic adaptive immune system known as CRISPR/Cas, enable targeted genome engineering in cells and organisms. RGENs are ribonucleoproteins that consist of guide RNA and Cas9, a protein component originated from Streptococcus pyogenes. These enz...

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Detalles Bibliográficos
Autores principales: Cho, Seung Woo, Kim, Sojung, Kim, Yongsub, Kweon, Jiyeon, Kim, Heon Seok, Bae, Sangsu, Kim, Jin-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875854/
https://www.ncbi.nlm.nih.gov/pubmed/24253446
http://dx.doi.org/10.1101/gr.162339.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875854/
https://www.ncbi.nlm.nih.gov/pubmed/24253446
http://dx.doi.org/10.1101/gr.162339.113

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