Autophagy variation within a cell population determines cell fate via selective degradation of Fap-1

Autophagy regulates cell death both positively and negatively, but the molecular basis for this paradox remains inadequately characterized. We demonstrate here that transient cell-to-cell variations in autophagy can either promote cell death or survival depending on the stimulus and cell type. By se...

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Detalles Bibliográficos
Autores principales: Gump, Jacob M., Staskiewicz, Leah, Morgan, Michael J., Bamberg, Alison, Riches, David W. H., Thorburn, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876036/
https://www.ncbi.nlm.nih.gov/pubmed/24316673
http://dx.doi.org/10.1038/ncb2886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876036/
https://www.ncbi.nlm.nih.gov/pubmed/24316673
http://dx.doi.org/10.1038/ncb2886

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