Human Interleukin 23 Receptor Induces Cell Apoptosis in Mammalian Cells by Intrinsic Mitochondrial Pathway Associated with the Down-Regulation of RAS/Mitogen-Activated Protein Kinase and Signal Transducers and Activators of Transcription factor 3 Signaling Pathways

The composition of IL-23R complex is similar to that of the IL-12 receptor (IL-12R) complex with a shared IL-12R-β1 chain. The IL-12R-β1 heterodimerizes with IL-23R and IL-12R-β2 to form IL-23R and IL-12R complexes, respectively. The IL-12R-β2 has been shown to function as a tumor suppressor gene an...

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Detalles Bibliográficos
Autores principales: Shi, Wei-Ye, Che, Chang-Yan, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876134/
https://www.ncbi.nlm.nih.gov/pubmed/24351840
http://dx.doi.org/10.3390/ijms141224656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876134/
https://www.ncbi.nlm.nih.gov/pubmed/24351840
http://dx.doi.org/10.3390/ijms141224656

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