Importance of H-Abstraction in the Final Step of Nitrosoalkane Formation in the Mechanism-Based Inactivation of Cytochrome P450 by Amine-Containing Drugs

The metabolism of amine-containing drugs by cytochrome P450 enzymes (P450s) is prone to form a nitrosoalkane metabolic intermediate (MI), which subsequently coordinates to the heme iron of a P450, to produce a metabolic-intermediate complex (MIC). This type of P450 inhibition, referred to as mechani...

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Detalles Bibliográficos
Autores principales: Hirao, Hajime, Thellamurege, Nandun M., Chuanprasit, Pratanphorn, Xu, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876136/
https://www.ncbi.nlm.nih.gov/pubmed/24351842
http://dx.doi.org/10.3390/ijms141224692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876136/
https://www.ncbi.nlm.nih.gov/pubmed/24351842
http://dx.doi.org/10.3390/ijms141224692

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