The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies

Telomerase, comprising a reverse transcriptase protein (TERT) and an RNA template, plays a critical role during senescence and carcinogenesis; however, the mechanisms by which telomerase is regulated remain to be elucidated. Several signaling pathways are involved in the activation of TERT at multis...

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Detalles Bibliográficos
Autores principales: Yamada, Osamu, Kawauchi, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876434/
https://www.ncbi.nlm.nih.gov/pubmed/24416646
http://dx.doi.org/10.4161/jkst.25256
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author Yamada, Osamu
Kawauchi, Kiyotaka
author_facet Yamada, Osamu
Kawauchi, Kiyotaka
author_sort Yamada, Osamu
collection PubMed
description Telomerase, comprising a reverse transcriptase protein (TERT) and an RNA template, plays a critical role during senescence and carcinogenesis; however, the mechanisms by which telomerase is regulated remain to be elucidated. Several signaling pathways are involved in the activation of TERT at multistep levels. The JAK-STAT pathway is indispensable for mediating signals through growth factor and cytokine receptors during the development of hematopoietic cells, and its activity is frequently upregulated in hematological malignancies. Here, we review the role of the JAK-STAT pathway and related signaling cascades in the regulation of telomerase in hematological malignancies.
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spelling pubmed-38764342014-01-10 The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies Yamada, Osamu Kawauchi, Kiyotaka JAKSTAT Review Telomerase, comprising a reverse transcriptase protein (TERT) and an RNA template, plays a critical role during senescence and carcinogenesis; however, the mechanisms by which telomerase is regulated remain to be elucidated. Several signaling pathways are involved in the activation of TERT at multistep levels. The JAK-STAT pathway is indispensable for mediating signals through growth factor and cytokine receptors during the development of hematopoietic cells, and its activity is frequently upregulated in hematological malignancies. Here, we review the role of the JAK-STAT pathway and related signaling cascades in the regulation of telomerase in hematological malignancies. Landes Bioscience 2013-10-01 2013-06-12 /pmc/articles/PMC3876434/ /pubmed/24416646 http://dx.doi.org/10.4161/jkst.25256 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Yamada, Osamu
Kawauchi, Kiyotaka
The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
title The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
title_full The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
title_fullStr The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
title_full_unstemmed The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
title_short The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
title_sort role of the jak-stat pathway and related signal cascades in telomerase activation during the development of hematologic malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876434/
https://www.ncbi.nlm.nih.gov/pubmed/24416646
http://dx.doi.org/10.4161/jkst.25256
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