STAT2 phosphorylation and signaling

STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and transcriptional activation of IFN stimulated genes...

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Detalles Bibliográficos
Autores principales: Steen, Håkan C, Gamero, Ana M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876438/
https://www.ncbi.nlm.nih.gov/pubmed/24416652
http://dx.doi.org/10.4161/jkst.25790
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author Steen, Håkan C
Gamero, Ana M
author_facet Steen, Håkan C
Gamero, Ana M
author_sort Steen, Håkan C
collection PubMed
description STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and transcriptional activation of IFN stimulated genes. Evidence of additional STAT2 phosphorylation sites has emerged as well as novel roles for STAT2 separate from the classical ISGF3-signaling. This review aims to summarize knowledge of phosphorylation-mediated STAT2-regulation and future avenues of related STAT2 research.
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spelling pubmed-38764382014-01-10 STAT2 phosphorylation and signaling Steen, Håkan C Gamero, Ana M JAKSTAT Review STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and transcriptional activation of IFN stimulated genes. Evidence of additional STAT2 phosphorylation sites has emerged as well as novel roles for STAT2 separate from the classical ISGF3-signaling. This review aims to summarize knowledge of phosphorylation-mediated STAT2-regulation and future avenues of related STAT2 research. Landes Bioscience 2013-10-01 2013-08-12 /pmc/articles/PMC3876438/ /pubmed/24416652 http://dx.doi.org/10.4161/jkst.25790 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Steen, Håkan C
Gamero, Ana M
STAT2 phosphorylation and signaling
title STAT2 phosphorylation and signaling
title_full STAT2 phosphorylation and signaling
title_fullStr STAT2 phosphorylation and signaling
title_full_unstemmed STAT2 phosphorylation and signaling
title_short STAT2 phosphorylation and signaling
title_sort stat2 phosphorylation and signaling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876438/
https://www.ncbi.nlm.nih.gov/pubmed/24416652
http://dx.doi.org/10.4161/jkst.25790
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