Endothelial Dysfunction Exacerbates Renal Interstitial Fibrosis through Enhancing Fibroblast Smad3 Linker Phosphorylation in the Mouse Obstructed Kidney

Endothelial dysfunction and enhanced transforming growth factor-β (TGF-β)/Smad3 signalling are common features of progressive renal fibrosis. This study investigated a potential link between these mechanisms. In unilateral ureteric obstruction (UUO) we observed an acute (6 hr) down-regulation of nit...

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Detalles Bibliográficos
Autores principales: Sun, Yu Bo Yang, Qu, Xinli, Li, Xueling, Nikolic-Paterson, David J., Li, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877161/
https://www.ncbi.nlm.nih.gov/pubmed/24391884
http://dx.doi.org/10.1371/journal.pone.0084063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877161/
https://www.ncbi.nlm.nih.gov/pubmed/24391884
http://dx.doi.org/10.1371/journal.pone.0084063

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