Cargando…

HIV-1 Env DNA Vaccine plus Protein Boost Delivered by EP Expands B- and T-Cell Responses and Neutralizing Phenotype In Vivo

An effective HIV vaccine will most likely require the induction of strong T-cell responses, broadly neutralizing antibodies (bNAbs), and the elicitation of antibody-dependent cellular cytotoxicity (ADCC). Previously, we demonstrated the induction of strong HIV/SIV cellular immune responses in macaqu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muthumani, Kar, Wise, Megan C., Broderick, Kate E., Hutnick, Natalie, Goodman, Jonathan, Flingai, Seleeke, Yan, Jian, Bian, Chaoran B., Mendoza, Janess, Tingey, Colleen, Wilson, Christine, Wojtak, Krzysztof, Sardesai, Niranjan Y., Weiner, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877240/ https://www.ncbi.nlm.nih.gov/pubmed/24391921 http://dx.doi.org/10.1371/journal.pone.0084234

Ejemplares similares

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy
por: Flingai, Seleeke, et al.
Publicado: (2015)

Synthetic DNA Vaccines: Improved Vaccine Potency by Electroporation and Co-Delivered Genetic Adjuvants
por: Flingai, Seleeke, et al.
Publicado: (2013)

Co-Administration of Molecular Adjuvants Expressing NF-Kappa B Subunit p65/RelA or Type-1 Transactivator T-bet Enhance Antigen Specific DNA Vaccine-Induced Immunity
por: Shedlock, Devon J., et al.
Publicado: (2014)

Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus
por: Muthumani, Karuppiah, et al.
Publicado: (2016)

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
por: Elliott, Sarah T. C., et al.
Publicado: (2017)

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model
por: Patel, Ami, et al.
Publicado: (2017)

E-DNA IM or ID delivery prime enhances antibody and T cell responses following recombinant gp120 env boost
por: Hutnick, NA, et al.
Publicado: (2012)

Minimally invasive and surface electroporation delivery of DNA vaccines for the induction of robust humoral immune responses against HIV antigens
por: Sardesai, NY, et al.
Publicado: (2012)

HIV Env conserved element DNA vaccine alters immunodominance in macaques
por: Hu, Xintao, et al.
Publicado: (2017)

436. Developing a Synthetic DNA Vaccine for an Emerging Pathogen - Middle East Respiratory Syndrome
por: Reuschel, Emma L., et al.
Publicado: (2016)

Comparison of cellular and humoral immune responses induced by primary, consensus or mosaic HIV-1 Env DNA vaccines
por: Yan, J, et al.
Publicado: (2012)

Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics
por: Khoshnejad, Makan, et al.
Publicado: (2019)

Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation
por: Mendoza, Janess M., et al.
Publicado: (2013)

A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation
por: Bhojnagarwala, Pratik S., et al.
Publicado: (2021)

A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin
por: McCoy, Jay R, et al.
Publicado: (2014)

Robust antibody and cellular responses with an improved DNA vaccine alone
por: Hutnick, N, et al.
Publicado: (2012)

DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response
por: Smith, Trevor RF, et al.
Publicado: (2014)

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques
por: Hu, Xintao, et al.
Publicado: (2018)

Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model
por: Louis, Lumena, et al.
Publicado: (2019)

Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques
por: Valentin, Antonio, et al.
Publicado: (2015)

Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA
por: Aldon, Yoann, et al.
Publicado: (2021)

IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment
por: Perales-Puchalt, Alfredo, et al.
Publicado: (2018)

Envés
por: Amara, Luigi, 1971-
Publicado: (2003)

Characterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin
por: Schultheis, Katherine, et al.
Publicado: (2016)

Novel Synthetic DNA Immunogens Targeting Latent Expressed Antigens of Epstein–Barr Virus Elicit Potent Cellular Responses and Inhibit Tumor Growth
por: Wojtak, Krzysztof, et al.
Publicado: (2019)

A Heterologous Prime/Boost Vaccination Strategy Enhances the Immunogenicity of Therapeutic Vaccines for Hepatitis C Virus
por: Fournillier, Anne, et al.
Publicado: (2013)

Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody
por: Muthumani, Kar, et al.
Publicado: (2017)

P04-24. Frequencies of HIV Env-specific B cells and neutralizing antibodies during DNA-prime/protein-boost immunization with three different Env immunogens*
por: Tawde, P, et al.
Publicado: (2009)

Simplifying checkpoint inhibitor delivery through in vivo generation of synthetic DNA-encoded monoclonal antibodies (DMAbs)
por: Perales-Puchalt, Alfredo, et al.
Publicado: (2019)

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation
por: Schommer, Nina N., et al.
Publicado: (2019)

Acceptability and Comfort Regarding Remotely Delivered PrEP Services in Mississippi
por: Giorlando, Kayla K., et al.
Publicado: (2023)

A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever
por: Cashman, Kathleen A., et al.
Publicado: (2017)

Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig
por: Xu, Ziyang, et al.
Publicado: (2018)

Elicitation of Both Anti HIV-1 Env Humoral and Cellular Immunities by Replicating Vaccinia Prime Sendai Virus Boost Regimen and Boosting by CD40Lm
por: Zhang, Xianfeng, et al.
Publicado: (2012)

Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency
por: Easterhoff, David, et al.
Publicado: (2020)

Protective immunity by an engineered DNA vaccine for Mayaro virus
por: Choi, Hyeree, et al.
Publicado: (2019)

Microparticles could deliver “self-boosting” vaccines
Publicado: (2022)

Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
por: Keele, Brandon F., et al.
Publicado: (2017)

Env-Specific Antibodies in Chronic Infection versus in Vaccination
por: Soldemo, Martina, et al.
Publicado: (2017)

Maternal intranasal immunization with HTLV-1 Env induces Env specific antibody responses in breast milk
por: Suzuki, Tadaki
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ro8s7gpnutq2mlfh16mrpi7tsg