ERO1α-dependent endoplasmic reticulum–mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1)

Procaspase-activating compound-1 (PAC-1) is the first direct caspase-activating compound discovered; using an in vitro cell-free system of caspase activation. Subsequently, this compound was shown to induce apoptosis in a variety of cancer cells with promising in vivo antitumor activity in canine ly...

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Detalles Bibliográficos
Autores principales: Seervi, M, Sobhan, P K, Joseph, J, Ann Mathew, K, Santhoshkumar, T R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877569/
https://www.ncbi.nlm.nih.gov/pubmed/24357799
http://dx.doi.org/10.1038/cddis.2013.502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877569/
https://www.ncbi.nlm.nih.gov/pubmed/24357799
http://dx.doi.org/10.1038/cddis.2013.502

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