TNF-α and IFN-s-Dependent Muscle Decay Is Linked to NF-κB- and STAT-1α-Stimulated Atrogin1 and MuRF1 Genes in C2C12 Myotubes

TNF-α was shown to stimulate mitogenicity in C2C12 myoblasts. Selected cytokines TNF-α, IFNα, or IFNγ reduced the expression of myosin heavy chain (MyHC IIa) when given together. Molecular mechanisms of cytokine activities were controlled by NF-κB and JAK/STAT signaling pathways, as metabolic inhibi...

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Detalles Bibliográficos
Autores principales: Pijet, Barbara, Pijet, Maja, Litwiniuk, Anna, Gajewska, Małgorzata, Pająk, Beata, Orzechowski, Arkadiusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877628/
https://www.ncbi.nlm.nih.gov/pubmed/24453411
http://dx.doi.org/10.1155/2013/171437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877628/
https://www.ncbi.nlm.nih.gov/pubmed/24453411
http://dx.doi.org/10.1155/2013/171437

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