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The role of disordered protein regions in the assembly of decapping complexes and RNP granules

The removal of the 5′ cap structure by the decapping enzyme DCP2 inhibits translation and generally commits the mRNA to irreversible 5′-to-3′ exonucleolytic degradation by XRN1. DCP2 catalytic activity is stimulated by DCP1, and these proteins form the conserved core of the decapping complex. Additi...

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Detalles Bibliográficos
Autores principales: Jonas, Stefanie, Izaurralde, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877753/
https://www.ncbi.nlm.nih.gov/pubmed/24352420
http://dx.doi.org/10.1101/gad.227843.113