eIF2B promotes eIF5 dissociation from eIF2•GDP to facilitate guanine nucleotide exchange for translation initiation

Protein synthesis factor eIF2 delivers initiator tRNA to the ribosome. Two proteins regulate its G-protein cycle: eIF5 has both GTPase-accelerating protein (GAP) and GDP dissociation inhibitor (GDI) functions, and eIF2B is the guanine nucleotide exchange factor (GEF). In this study, we used protein–...

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Detalles Bibliográficos
Autores principales: Jennings, Martin D., Zhou, Yu, Mohammad-Qureshi, Sarah S., Bennett, David, Pavitt, Graham D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877758/
https://www.ncbi.nlm.nih.gov/pubmed/24352424
http://dx.doi.org/10.1101/gad.231514.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877758/
https://www.ncbi.nlm.nih.gov/pubmed/24352424
http://dx.doi.org/10.1101/gad.231514.113

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