Hypoxia Reduces the Efficiency of Elisidepsin by Inhibiting Hydroxylation and Altering the Structure of Lipid Rafts

The mechanism of action of elisidepsin (PM02734, Irvalec(®)) is assumed to involve membrane permeabilization via attacking lipid rafts and hydroxylated lipids. Here we investigate the role of hypoxia in the mechanism of action of elisidepsin. Culturing under hypoxic conditions increased the half-max...

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Detalles Bibliográficos
Autores principales: Király, Anna, Váradi, Tímea, Hajdu, Tímea, Rühl, Ralph, Galmarini, Carlos M., Szöllősi, János, Nagy, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877891/
https://www.ncbi.nlm.nih.gov/pubmed/24317474
http://dx.doi.org/10.3390/md11124858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877891/
https://www.ncbi.nlm.nih.gov/pubmed/24317474
http://dx.doi.org/10.3390/md11124858

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