Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue

Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyro...

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Autores principales: Wyche, Thomas P., Standiford, Miranda, Hou, Yanpeng, Braun, Doug, Johnson, Delinda A., Johnson, Jeffrey A., Bugni, Tim S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877905/
https://www.ncbi.nlm.nih.gov/pubmed/24351907
http://dx.doi.org/10.3390/md11125089
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author Wyche, Thomas P.
Standiford, Miranda
Hou, Yanpeng
Braun, Doug
Johnson, Delinda A.
Johnson, Jeffrey A.
Bugni, Tim S.
author_facet Wyche, Thomas P.
Standiford, Miranda
Hou, Yanpeng
Braun, Doug
Johnson, Delinda A.
Johnson, Jeffrey A.
Bugni, Tim S.
author_sort Wyche, Thomas P.
collection PubMed
description Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, which is an important therapeutic approach for treatment of neurodegenerative diseases.
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spelling pubmed-38779052014-01-02 Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue Wyche, Thomas P. Standiford, Miranda Hou, Yanpeng Braun, Doug Johnson, Delinda A. Johnson, Jeffrey A. Bugni, Tim S. Mar Drugs Article Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, which is an important therapeutic approach for treatment of neurodegenerative diseases. MDPI 2013-12-16 /pmc/articles/PMC3877905/ /pubmed/24351907 http://dx.doi.org/10.3390/md11125089 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wyche, Thomas P.
Standiford, Miranda
Hou, Yanpeng
Braun, Doug
Johnson, Delinda A.
Johnson, Jeffrey A.
Bugni, Tim S.
Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue
title Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue
title_full Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue
title_fullStr Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue
title_full_unstemmed Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue
title_short Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue
title_sort activation of the nuclear factor e2-related factor 2 pathway by novel natural products halomadurones a–d and a synthetic analogue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877905/
https://www.ncbi.nlm.nih.gov/pubmed/24351907
http://dx.doi.org/10.3390/md11125089
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