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Consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review

BACKGROUND: Previous studies have been limited in reporting the association between chocolate consumption, measured by interviewer-administered questionnaire or serum theobromine, a biomarker for cocoa, and risk of preeclampsia, and have showed somewhat conflicting results. METHODS/DESIGN: A systema...

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Autores principales: Mogollon, Jaime Andres, Boivin, Catherine, Philippe, Kadhel, Turcotte, Stéphane, Lemieux, Simone, Blanchet, Claudine, Bujold, Emmanuel, Dodin, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878223/
https://www.ncbi.nlm.nih.gov/pubmed/24360219
http://dx.doi.org/10.1186/2046-4053-2-114
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author Mogollon, Jaime Andres
Boivin, Catherine
Philippe, Kadhel
Turcotte, Stéphane
Lemieux, Simone
Blanchet, Claudine
Bujold, Emmanuel
Dodin, Sylvie
author_facet Mogollon, Jaime Andres
Boivin, Catherine
Philippe, Kadhel
Turcotte, Stéphane
Lemieux, Simone
Blanchet, Claudine
Bujold, Emmanuel
Dodin, Sylvie
author_sort Mogollon, Jaime Andres
collection PubMed
description BACKGROUND: Previous studies have been limited in reporting the association between chocolate consumption, measured by interviewer-administered questionnaire or serum theobromine, a biomarker for cocoa, and risk of preeclampsia, and have showed somewhat conflicting results. METHODS/DESIGN: A systematic review of observational and experimental studies will be carried out. We will examine PubMed, Embase, and the entire Cochrane Library. Studies of chocolate consumption compared or not with placebo or low flavanol chocolate during pregnancy will be evaluated to investigate the effect of chocolate consumption in pregnant women on the risk of preeclampsia or pregnancy-induced hypertension. Screening for inclusion, data extraction, and quality assessment will be performed independently by two reviewers in consultation with a third reviewer. Validity of the studies will be ascertained by using the Cochrane Collaboration’s tool. Relative risk of preeclampsia will be the primary measure of treatment effect. Heterogeneity will be explored by subgroup analysis according to confounding factors and bias. DISCUSSION: This systematic review will contribute to establish the current state of knowledge concerning the possible association between chocolate consumption and prevention of preeclampsia. Furthermore, it will justify if additional experimental trials are necessary to better evaluate the benefits of chocolate consumption on the risk of preeclampsia. TRIAL REGISTRATION: This systematic review has been registered in the PROSPERO international prospective register of systematic reviews. The registration number is: CRD42013005338
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spelling pubmed-38782232014-01-03 Consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review Mogollon, Jaime Andres Boivin, Catherine Philippe, Kadhel Turcotte, Stéphane Lemieux, Simone Blanchet, Claudine Bujold, Emmanuel Dodin, Sylvie Syst Rev Protocol BACKGROUND: Previous studies have been limited in reporting the association between chocolate consumption, measured by interviewer-administered questionnaire or serum theobromine, a biomarker for cocoa, and risk of preeclampsia, and have showed somewhat conflicting results. METHODS/DESIGN: A systematic review of observational and experimental studies will be carried out. We will examine PubMed, Embase, and the entire Cochrane Library. Studies of chocolate consumption compared or not with placebo or low flavanol chocolate during pregnancy will be evaluated to investigate the effect of chocolate consumption in pregnant women on the risk of preeclampsia or pregnancy-induced hypertension. Screening for inclusion, data extraction, and quality assessment will be performed independently by two reviewers in consultation with a third reviewer. Validity of the studies will be ascertained by using the Cochrane Collaboration’s tool. Relative risk of preeclampsia will be the primary measure of treatment effect. Heterogeneity will be explored by subgroup analysis according to confounding factors and bias. DISCUSSION: This systematic review will contribute to establish the current state of knowledge concerning the possible association between chocolate consumption and prevention of preeclampsia. Furthermore, it will justify if additional experimental trials are necessary to better evaluate the benefits of chocolate consumption on the risk of preeclampsia. TRIAL REGISTRATION: This systematic review has been registered in the PROSPERO international prospective register of systematic reviews. The registration number is: CRD42013005338 BioMed Central 2013-12-20 /pmc/articles/PMC3878223/ /pubmed/24360219 http://dx.doi.org/10.1186/2046-4053-2-114 Text en Copyright © 2013 Mogollon et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Protocol
Mogollon, Jaime Andres
Boivin, Catherine
Philippe, Kadhel
Turcotte, Stéphane
Lemieux, Simone
Blanchet, Claudine
Bujold, Emmanuel
Dodin, Sylvie
Consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review
title Consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review
title_full Consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review
title_fullStr Consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review
title_full_unstemmed Consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review
title_short Consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review
title_sort consumption of chocolate in pregnant women and risk of preeclampsia: a systematic review
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878223/
https://www.ncbi.nlm.nih.gov/pubmed/24360219
http://dx.doi.org/10.1186/2046-4053-2-114
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