HIV integration and T cell death: additional commentary

Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature498...

Descripción completa

Detalles Bibliográficos
Autores principales: Cooper, Arik, García, Mayra, Petrovas, Constantinos, Yamamoto, Takuya, Koup, Richard A, Nabel, Gary J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878915/
https://www.ncbi.nlm.nih.gov/pubmed/24321564
http://dx.doi.org/10.1186/1742-4690-10-150
Descripción
Sumario:Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature498:376-379, 2013). They have raised several hypothetical points that we further clarify here.

Ejemplares similares