HIV integration and T cell death: additional commentary

Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature498...

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Detalles Bibliográficos
Autores principales: Cooper, Arik, García, Mayra, Petrovas, Constantinos, Yamamoto, Takuya, Koup, Richard A, Nabel, Gary J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878915/
https://www.ncbi.nlm.nih.gov/pubmed/24321564
http://dx.doi.org/10.1186/1742-4690-10-150
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author Cooper, Arik
García, Mayra
Petrovas, Constantinos
Yamamoto, Takuya
Koup, Richard A
Nabel, Gary J
author_facet Cooper, Arik
García, Mayra
Petrovas, Constantinos
Yamamoto, Takuya
Koup, Richard A
Nabel, Gary J
author_sort Cooper, Arik
collection PubMed
description Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature498:376-379, 2013). They have raised several hypothetical points that we further clarify here.
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spelling pubmed-38789152014-01-03 HIV integration and T cell death: additional commentary Cooper, Arik García, Mayra Petrovas, Constantinos Yamamoto, Takuya Koup, Richard A Nabel, Gary J Retrovirology Commentary Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature498:376-379, 2013). They have raised several hypothetical points that we further clarify here. BioMed Central 2013-12-09 /pmc/articles/PMC3878915/ /pubmed/24321564 http://dx.doi.org/10.1186/1742-4690-10-150 Text en Copyright © 2013 Cooper et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Cooper, Arik
García, Mayra
Petrovas, Constantinos
Yamamoto, Takuya
Koup, Richard A
Nabel, Gary J
HIV integration and T cell death: additional commentary
title HIV integration and T cell death: additional commentary
title_full HIV integration and T cell death: additional commentary
title_fullStr HIV integration and T cell death: additional commentary
title_full_unstemmed HIV integration and T cell death: additional commentary
title_short HIV integration and T cell death: additional commentary
title_sort hiv integration and t cell death: additional commentary
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878915/
https://www.ncbi.nlm.nih.gov/pubmed/24321564
http://dx.doi.org/10.1186/1742-4690-10-150
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