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HIV integration and T cell death: additional commentary
Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature498...
Autores principales: | Cooper, Arik, García, Mayra, Petrovas, Constantinos, Yamamoto, Takuya, Koup, Richard A, Nabel, Gary J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878915/ https://www.ncbi.nlm.nih.gov/pubmed/24321564 http://dx.doi.org/10.1186/1742-4690-10-150 |
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