Suppression of autophagy enhances preferential toxicity of paclitaxel to folliculin-deficient renal cancer cells

BACKGROUND: Paclitaxel, a widely used chemotherapeutic drug, can induce apoptosis in variety of cancer cells. A previous study has shown preferential toxicity of paclitaxel to FLCN-deficient kidney cancer cell line, UOK257. In this report, we investigate the cellular and molecular mechanism of pacli...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Si, Shuhui, Schoen, Sue, Chen, Jindong, Jin, Xun-Bo, Wu, Guan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879005/
https://www.ncbi.nlm.nih.gov/pubmed/24305604
http://dx.doi.org/10.1186/1756-9966-32-99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879005/
https://www.ncbi.nlm.nih.gov/pubmed/24305604
http://dx.doi.org/10.1186/1756-9966-32-99

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