Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy

Oligonucleotides homologous to 3′-telomere overhang (T-oligos) trigger inherent telomere-based DNA damage responses mediated by p53 and/or ATM and induce senescence or apoptosis in various cancerous cells. However, T-oligo has limited stability in vivo due to serum and intracellular nucleases. To de...

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Detalles Bibliográficos
Autores principales: Uppada, Srijayaprakash B, Erickson, Terrianne, Wojdyla, Luke, Moravec, David N, Song, Ziyuan, Cheng, Jianjun, Puri, Neelu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879016/
https://www.ncbi.nlm.nih.gov/pubmed/24391441
http://dx.doi.org/10.2147/IJN.S55133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879016/
https://www.ncbi.nlm.nih.gov/pubmed/24391441
http://dx.doi.org/10.2147/IJN.S55133

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