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Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy
Oligonucleotides homologous to 3′-telomere overhang (T-oligos) trigger inherent telomere-based DNA damage responses mediated by p53 and/or ATM and induce senescence or apoptosis in various cancerous cells. However, T-oligo has limited stability in vivo due to serum and intracellular nucleases. To de...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879016/ https://www.ncbi.nlm.nih.gov/pubmed/24391441 http://dx.doi.org/10.2147/IJN.S55133 |