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Differentiation between genomic and non-genomic feedback controls yields an HPA axis model featuring Hypercortisolism as an irreversible bistable switch

BACKGROUND: The hypothalamic-pituitary-adrenal axis (HPA axis) is a major part of the neuroendocrine system responsible for the regulation of the response to physical or mental stress and for the control of the synthesis of the stress hormone cortisol. Dysfunctions of the HPA axis characterized by e...

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Detalles Bibliográficos
Autores principales: Zarzer, Clemens A, Puchinger, Martin G, Köhler, Gottfried, Kügler, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879227/
https://www.ncbi.nlm.nih.gov/pubmed/24209391
http://dx.doi.org/10.1186/1742-4682-10-65