A Model of Photon Cell Killing Based on the Spatio-Temporal Clustering of DNA Damage in Higher Order Chromatin Structures

We present a new approach to model dose rate effects on cell killing after photon radiation based on the spatio-temporal clustering of DNA double strand breaks (DSBs) within higher order chromatin structures of approximately 1–2 Mbp size, so called giant loops. The main concept of this approach cons...

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Detalles Bibliográficos
Autores principales: Herr, Lisa, Friedrich, Thomas, Durante, Marco, Scholz, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879277/
https://www.ncbi.nlm.nih.gov/pubmed/24392100
http://dx.doi.org/10.1371/journal.pone.0083923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879277/
https://www.ncbi.nlm.nih.gov/pubmed/24392100
http://dx.doi.org/10.1371/journal.pone.0083923

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