A Single Amino Acid in the Stalk Region of the H1N1pdm Influenza Virus HA Protein Affects Viral Fusion, Stability and Infectivity

The 2009 H1N1 pandemic (H1N1pdm) viruses have evolved to contain an E47K substitution in the HA2 subunit of the stalk region of the hemagglutinin (HA) protein. The biological significance of this single amino acid change was investigated by comparing A/California/7/2009 (HA2-E47) with a later strain...

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Detalles Bibliográficos
Autores principales: Cotter, Christopher R., Jin, Hong, Chen, Zhongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879363/
https://www.ncbi.nlm.nih.gov/pubmed/24391498
http://dx.doi.org/10.1371/journal.ppat.1003831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879363/
https://www.ncbi.nlm.nih.gov/pubmed/24391498
http://dx.doi.org/10.1371/journal.ppat.1003831

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