Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection

Hepatitis B virus (HBV) persistence is facilitated by exhaustion of CD8 T cells that express the inhibitory receptor programmed cell death-1 (PD-1). Improvement of the HBV-specific T cell function has been obtained in vitro by inhibiting the PD-1/PD-ligand 1 (PD-L1) interaction. In this study, we ex...

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Detalles Bibliográficos
Autores principales: Liu, Jia, Zhang, Ejuan, Ma, Zhiyong, Wu, Weimin, Kosinska, Anna, Zhang, Xiaoyong, Möller, Inga, Seiz, Pia, Glebe, Dieter, Wang, Baoju, Yang, Dongliang, Lu, Mengji, Roggendorf, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879364/
https://www.ncbi.nlm.nih.gov/pubmed/24391505
http://dx.doi.org/10.1371/journal.ppat.1003856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879364/
https://www.ncbi.nlm.nih.gov/pubmed/24391505
http://dx.doi.org/10.1371/journal.ppat.1003856

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