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STING-Dependent Type I IFN Production Inhibits Cell-Mediated Immunity to Listeria monocytogenes

Infection with Listeria monocytogenes strains that enter the host cell cytosol leads to a robust cytotoxic T cell response resulting in long-lived cell-mediated immunity (CMI). Upon entry into the cytosol, L. monocytogenes secretes cyclic diadenosine monophosphate (c-di-AMP) which activates the inna...

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Detalles Bibliográficos
Autores principales: Archer, Kristina A., Durack, Juliana, Portnoy, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879373/
https://www.ncbi.nlm.nih.gov/pubmed/24391507
http://dx.doi.org/10.1371/journal.ppat.1003861