Cargando…

Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 Impacts Its Immunological Properties

Many allergens share several biophysical characteristics, including the capability to undergo oligomerization. The dimerization mechanism in Bet v 1 and its allergenic properties are so far poorly understood. Here, we report crystal structures of dimeric Bet v 1, revealing a noncanonical incorporati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kofler, Stefan, Ackaert, Chloé, Samonig, Martin, Asam, Claudia, Briza, Peter, Horejs-Hoeck, Jutta, Cabrele, Chiara, Ferreira, Fatima, Duschl, Albert, Huber, Christian, Brandstetter, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879576/ https://www.ncbi.nlm.nih.gov/pubmed/24253036 http://dx.doi.org/10.1074/jbc.M113.518795

Ejemplares similares

The Impact of Nitration on the Structure and Immunogenicity of the Major Birch Pollen Allergen Bet v 1.0101
por: Ackaert, Chloé, et al.
Publicado: (2014)

Nitration of the Birch Pollen Allergen Bet v 1.0101: Efficiency and Site-Selectivity of Liquid and Gaseous Nitrating Agents
por: Reinmuth-Selzle, Kathrin, et al.
Publicado: (2014)

Ligand Binding Modulates the Structural Dynamics and Compactness of the Major Birch Pollen Allergen
por: Grutsch, Sarina, et al.
Publicado: (2014)

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition
por: Dall, Elfriede, et al.
Publicado: (2020)

Separation and characterization of nitrated variants of the major birch pollen allergen by CZE-ESI-μTOF MS
por: Gusenkov, Sergey, et al.
Publicado: (2013)

Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1
por: Kofler, Stefan, et al.
Publicado: (2012)

Fibulin 5 Forms a Compact Dimer in Physiological Solutions
por: Jones, Richard P. O., et al.
Publicado: (2009)

The Concave Face of Decorin Mediates Reversible Dimerization and Collagen Binding
por: Islam, Mehwaesh, et al.
Publicado: (2013)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2008)

The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking
por: Fukutani, Yosuke, et al.
Publicado: (2019)

Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer
por: Sherekar, Mukul, et al.
Publicado: (2020)

The Mitosis and Neurodevelopment Proteins NDE1 and NDEL1 Form Dimers, Tetramers, and Polymers with a Folded Back Structure in Solution
por: Soares, Dinesh C., et al.
Publicado: (2012)

Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T
por: Eckhard, Ulrich, et al.
Publicado: (2013)

Recombinant Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Forms a Dimer through Its C-terminal Domain
por: Yu, I-Mei, et al.
Publicado: (2005)

Crystal Structure of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Dimerization Domain Reveals Evolutionary Linkage between Corona- and Arteriviridae
por: Yu, I-Mei, et al.
Publicado: (2006)

Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold
por: Stieglitz, Benjamin, et al.
Publicado: (2012)

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL(pro)): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS
por: Tomar, Sakshi, et al.
Publicado: (2015)

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization: BIOCHEMICAL AND THERMODYNAMIC INVESTIGATION IN CONJUNCTION WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2005)

Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen
por: Machado, Yoan, et al.
Publicado: (2016)

Structure-Function Analyses of Human Kallikrein-related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity
por: Skala, Wolfgang, et al.
Publicado: (2014)

Dissection Study on the Severe Acute Respiratory Syndrome 3C-like Protease Reveals the Critical Role of the Extra Domain in Dimerization of the Enzyme: DEFINING THE EXTRA DOMAIN AS A NEW TARGET FOR DESIGN OF HIGHLY SPECIFIC PROTEASE INHIBITORS
por: Shi, Jiahai, et al.
Publicado: (2004)

Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain
por: Richter, Kirsten, et al.
Publicado: (2020)

The History and Science of the Major Birch Pollen Allergen Bet v 1
por: Breiteneder, Heimo, et al.
Publicado: (2023)

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations
por: Hocking, Henry G., et al.
Publicado: (2008)

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme
por: Carlson, Brian L., et al.
Publicado: (2008)

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells
por: Gomes, Mariana P. B., et al.
Publicado: (2008)

Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90
por: Cunningham, Christian N., et al.
Publicado: (2008)

A Common Theme in Interaction of Bacterial Immunoglobulin-binding Proteins with Immunoglobulins Illustrated in the Equine System
por: Lewis, Melanie J., et al.
Publicado: (2008)

A Common β-Sheet Architecture Underlies in Vitro and in Vivo β(2)-Microglobulin Amyloid Fibrils
por: Jahn, Thomas R., et al.
Publicado: (2008)

Appearance and Propagation of Polyglutamine-based Amyloids in Yeast: TYROSINE RESIDUES ENABLE POLYMER FRAGMENTATION
por: Alexandrov, Ilya M., et al.
Publicado: (2008)

Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia
por: Grummitt, Charles G., et al.
Publicado: (2008)

Structure of the Human 26S Proteasome: SUBUNIT RADIAL DISPLACEMENTS OPEN THE GATE INTO THE PROTEOLYTIC CORE
por: da Fonseca, Paula C. A., et al.
Publicado: (2008)

Crystal Structure of Colicin M, a Novel Phosphatase Specifically Imported by Escherichia coli>
por: Zeth, Kornelius, et al.
Publicado: (2008)

Structure-Function Analysis of the C3 Binding Region of Staphylococcus aureus Immune Subversion Protein Sbi
por: Upadhyay, Abhishek, et al.
Publicado: (2008)

Structural Constraints for the Binding of Short Peptides to Claudin-4 Revealed by Surface Plasmon Resonance
por: Ling, Jun, et al.
Publicado: (2008)

Electrostatic and Lipid Anchor Contributions to the Interaction of Transducin with Membranes: MECHANISTIC IMPLICATIONS FOR ACTIVATION AND TRANSLOCATION
por: Kosloff, Mickey, et al.
Publicado: (2008)

Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor: EQUIPOTENT TO C34 AND T-20 IN VITRO WITH SUSTAINED ACTIVITY IN SCID-HU THY/LIV MICE
por: Stoddart, Cheryl A., et al.
Publicado: (2008)

Deciphering the Ligand-binding Sites in the Borrelia burgdorferi Complement Regulator-acquiring Surface Protein 2 Required for Interactions with the Human Immune Regulators Factor H and Factor H-like Protein 1
por: Siegel, Corinna, et al.
Publicado: (2008)

Iron-mediated Aggregation and a Localized Structural Change Characterize Ferritin from a Mutant Light Chain Polypeptide That Causes Neurodegeneration
por: Baraibar, Martin A., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_3o6hb5bpovmci3inoo3te2gob9