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Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome?
Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879979/ https://www.ncbi.nlm.nih.gov/pubmed/24273314 http://dx.doi.org/10.1093/gbe/evt193 |
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author | Chen, Xiaoshu Zhang, Jianzhi |
author_facet | Chen, Xiaoshu Zhang, Jianzhi |
author_sort | Chen, Xiaoshu |
collection | PubMed |
description | Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collisions, as is observed in most bacterial genomes examined. However, why are there still lagging strand encoded genes? Paul et al. recently proposed that these genes take advantage of the increased mutagenesis resulting from head-on collisions and are thus adaptively encoded on the lagging strand. We show that the evidence they provided is invalid and that the existence of lagging strand encoded genes is explainable by a balance between deleterious mutations that bring genes from the leading to the lagging strand and purifying selection purging such mutants. Therefore, the adaptive hypothesis is neither theoretically needed nor empirically supported. |
format | Online Article Text |
id | pubmed-3879979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38799792014-01-03 Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome? Chen, Xiaoshu Zhang, Jianzhi Genome Biol Evol Letter Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collisions, as is observed in most bacterial genomes examined. However, why are there still lagging strand encoded genes? Paul et al. recently proposed that these genes take advantage of the increased mutagenesis resulting from head-on collisions and are thus adaptively encoded on the lagging strand. We show that the evidence they provided is invalid and that the existence of lagging strand encoded genes is explainable by a balance between deleterious mutations that bring genes from the leading to the lagging strand and purifying selection purging such mutants. Therefore, the adaptive hypothesis is neither theoretically needed nor empirically supported. Oxford University Press 2013 2013-11-22 /pmc/articles/PMC3879979/ /pubmed/24273314 http://dx.doi.org/10.1093/gbe/evt193 Text en © The Author(s) 2013. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Letter Chen, Xiaoshu Zhang, Jianzhi Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome? |
title | Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome? |
title_full | Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome? |
title_fullStr | Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome? |
title_full_unstemmed | Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome? |
title_short | Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome? |
title_sort | why are genes encoded on the lagging strand of the bacterial genome? |
topic | Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879979/ https://www.ncbi.nlm.nih.gov/pubmed/24273314 http://dx.doi.org/10.1093/gbe/evt193 |
work_keys_str_mv | AT chenxiaoshu whyaregenesencodedonthelaggingstrandofthebacterialgenome AT zhangjianzhi whyaregenesencodedonthelaggingstrandofthebacterialgenome |