Toward an Understanding of Agonist Binding to Human Orexin-1 and Orexin-2 Receptors with G-Protein-Coupled Receptor Modeling and Site-Directed Mutagenesis

[Image: see text] The class A G-protein-coupled receptors (GPCRs) Orexin-1 (OX1) and Orexin-2 (OX2) are located predominantly in the brain and are linked to a range of different physiological functions, including the control of feeding, energy metabolism, modulation of neuro-endocrine function, and...

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Detalles Bibliográficos
Autores principales: Heifetz, Alexander, Barker, Oliver, Morris, G. Benjamin, Law, Richard J., Slack, Mark, Biggin, Philip C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880013/
https://www.ncbi.nlm.nih.gov/pubmed/24144388
http://dx.doi.org/10.1021/bi401119m

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880013/
https://www.ncbi.nlm.nih.gov/pubmed/24144388
http://dx.doi.org/10.1021/bi401119m

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