A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort

BACKGROUND: Genetic modifiers are important clues for the identification of therapeutic targets in neurodegenerative diseases. Huntington disease (HD) is one of the most common autosomal dominant inherited neurodegenerative diseases. The clinical symptoms include motor abnormalities, cognitive decli...

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Detalles Bibliográficos
Autores principales: Weydt, Patrick, Soyal, Selma M, Landwehrmeyer, G Bernhard, Patsch, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880172/
https://www.ncbi.nlm.nih.gov/pubmed/24383721
http://dx.doi.org/10.1186/1471-2377-14-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880172/
https://www.ncbi.nlm.nih.gov/pubmed/24383721
http://dx.doi.org/10.1186/1471-2377-14-1

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