Cargando…

C/EBPα Is Dispensable for the Ontogeny of PD-1+ CD4+ Memory T Cells but Restricts Their Expansion in an Age-Dependent Manner

Ageing and cancer is often associated with altered T cell distributions and this phenomenon has been suggested to be the main driver in the development of immunosenescence. Memory phenotype PD-1+ CD4+ T cells accumulate with age and during leukemic development, and they might account for the attenua...

Descripción completa

Detalles Bibliográficos
Autores principales: Norrie, Ida Christine, Ohlsson, Ewa, Nielsen, Olaf, Hasemann, Marie Sigurd, Porse, Bo T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880335/
https://www.ncbi.nlm.nih.gov/pubmed/24404186
http://dx.doi.org/10.1371/journal.pone.0084728