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Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion
The Ca(2+) channel-binding domain 3 (CBD3) peptide, derived from the collapsin response mediator protein 2 (CRMP-2), is a recently discovered voltage-gated Ca(2+) channel (VGCC) blocker with a preference for Ca(V)2.2. Rodent administration of CBD3 conjugated to cell penetrating motif TAT (TAT-CBD3)...
Autores principales: | Fischer, G, Pan, B, Vilceanu, D, Hogan, Q H, Yu, H |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881029/ https://www.ncbi.nlm.nih.gov/pubmed/24152582 http://dx.doi.org/10.1038/gt.2013.56 |
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