The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and act...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881336/ https://www.ncbi.nlm.nih.gov/pubmed/24404427 http://dx.doi.org/10.4161/onci.26442 |
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author | Wong, Hing C Jeng, Emily K Rhode, Peter R |
author_facet | Wong, Hing C Jeng, Emily K Rhode, Peter R |
author_sort | Wong, Hing C |
collection | PubMed |
description | ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and activation of memory CD8(+) T cells while converting them into innate immune effector cells that exhibit robust antineoplastic activity. |
format | Online Article Text |
id | pubmed-3881336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-38813362014-01-08 The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity Wong, Hing C Jeng, Emily K Rhode, Peter R Oncoimmunology Author's View ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and activation of memory CD8(+) T cells while converting them into innate immune effector cells that exhibit robust antineoplastic activity. Landes Bioscience 2013-11-01 2013-10-09 /pmc/articles/PMC3881336/ /pubmed/24404427 http://dx.doi.org/10.4161/onci.26442 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Author's View Wong, Hing C Jeng, Emily K Rhode, Peter R The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity |
title | The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity |
title_full | The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity |
title_fullStr | The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity |
title_full_unstemmed | The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity |
title_short | The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity |
title_sort | il-15-based superagonist alt-803 promotes the antigen-independent conversion of memory cd8(+) t cells into innate-like effector cells with antitumor activity |
topic | Author's View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881336/ https://www.ncbi.nlm.nih.gov/pubmed/24404427 http://dx.doi.org/10.4161/onci.26442 |
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