The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity

ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and act...

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Detalles Bibliográficos
Autores principales: Wong, Hing C, Jeng, Emily K, Rhode, Peter R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881336/
https://www.ncbi.nlm.nih.gov/pubmed/24404427
http://dx.doi.org/10.4161/onci.26442
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author Wong, Hing C
Jeng, Emily K
Rhode, Peter R
author_facet Wong, Hing C
Jeng, Emily K
Rhode, Peter R
author_sort Wong, Hing C
collection PubMed
description ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and activation of memory CD8(+) T cells while converting them into innate immune effector cells that exhibit robust antineoplastic activity.
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spelling pubmed-38813362014-01-08 The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity Wong, Hing C Jeng, Emily K Rhode, Peter R Oncoimmunology Author's View ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and activation of memory CD8(+) T cells while converting them into innate immune effector cells that exhibit robust antineoplastic activity. Landes Bioscience 2013-11-01 2013-10-09 /pmc/articles/PMC3881336/ /pubmed/24404427 http://dx.doi.org/10.4161/onci.26442 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Wong, Hing C
Jeng, Emily K
Rhode, Peter R
The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
title The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
title_full The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
title_fullStr The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
title_full_unstemmed The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
title_short The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
title_sort il-15-based superagonist alt-803 promotes the antigen-independent conversion of memory cd8(+) t cells into innate-like effector cells with antitumor activity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881336/
https://www.ncbi.nlm.nih.gov/pubmed/24404427
http://dx.doi.org/10.4161/onci.26442
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