Presymptomatic Treatment with Acetylcholinesterase Antisense Oligonucleotides Prolongs Survival in ALS (G93A-SOD1) Mice

Objective. Previous research suggests that acetylcholinesterase (AChE) may be involved in ALS pathogenesis. AChE enzyme inhibitors can upregulate AChE transcription which in certain contexts can have deleterious (noncatalytic) effects, making them theoretically harmful in ALS, whilst AChE antisense-...

Descripción completa

Detalles Bibliográficos
Autores principales: Marc, Gotkine, Leah, Rozenstein, Ofira, Einstein, Oded, Abramsky, Zohar, Argov, Hanna, Rosenmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881454/
https://www.ncbi.nlm.nih.gov/pubmed/24455732
http://dx.doi.org/10.1155/2013/845345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881454/
https://www.ncbi.nlm.nih.gov/pubmed/24455732
http://dx.doi.org/10.1155/2013/845345

Ejemplares similares