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Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progressio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881600/ https://www.ncbi.nlm.nih.gov/pubmed/24404426 http://dx.doi.org/10.4161/onci.26383 |